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Department of Molecular Biology and Biochemistry
8166 South Science Building, 778.782.5630 Tel, 778.782.5583 Fax,
Chair
B.P. Brandhorst AB (Harv), PhD (Calif)
Graduate Program Chair
N. Harden BSc (Br Col), PhD (Camb)
Faculty and Areas of Research
See “Department of Molecular Biology and Biochemistry” on page 200 for a complete list of faculty.
D.L. Baillie – developmental genetics, genomics
C.T. Beh – cholesterol molecular genetics and genomics
B.P. Brandhorst – cell biology of development
F.S.L. Brinkman – bacterial genomics and bioinformatics
M.A. Brockman – virology, immunology of HIV
N.J. Chen – bioinformatics, genome architecture, expression and evolution
J. Choy – immunology, cardiovascular physiology
R.B. Cornell – membrane biochemistry, protein lipid interactions
L. Craig – structure assembly and function of bacterial pili and related virulence factors
W.S. Davidson – molecular, population and evolutionary genetics
S.M. Gorski – developmental and cellular genetics, apoptosis
N. Harden – developmental genetics, signal transduction
N.C. Hawkins – developmental genetics
R. Holt – synthetic biology. DNA sequencing, neurogenomics
B.M. Honda – molecular biology and gene regulation
S. Jones – bioinformatics and genomics of cancer
M.R. Leroux – protein structure and function
M.W. Paetzel – protein structure and function
F.F. Pio – proteomics, bioinformatics, apoptosis
L.M. Quarmby – cell biology
J.K. Scott***– immunochemistry, immunology
D. Sen* – nucleic acid biochemistry, chromosome structure
J.L. Thewalt** – membrane biophysics, nuclear magnetic resonance
P.J. Unrau – RNA-catalyzed chemical reactions, early metabolism, self-replicating systems
E.M. Verheyen – Drosophila developmental genetics, cell fate determination
E.C. Young – Ligand-induced conformational changes in ion channels
Adjunct Faculty
T. Borgford – protein biochemistry, biotechnology
R. Bruskiewich – bioinformatics, rice genomics
D. Granville – cardiovascular diseases, apoptosis
M. Hirst – genomics, protein interactions
K.Y. Leung – bacterial pathogenesis and secretion
M. Marra – functional genomics of cancer, bioinformatics, large scale DNA mapping and sequencing
J.Mills – cell signalling, neuro development
G.B. Morin – proteomics, protein interactions
F. Ouellette – bioinformatics, data management tools
E. Stringham – developmental and molecular genetics of cellular signalling
Associate Members
For areas of research, refer to the department listed.
T.V. Beischlag, Faculty of Health Sciences
A.J. Bennet, Department of Chemistry
N.R. Branda, Department of Chemistry
F. Breden, Department of Biological Sciences
T. Claydon, Department of Biomedical Physiology and Kinesiology
E.G. Emberly, Department of Physics
N. Forde, Department of Physics
N.H. Haunerland, Department of Biological Sciences
C. Krieger, Department of Biomedical Physiology and Kinesiology
P.C.H. Li, Department of Chemistry
C.A. Lowenberger, Department of Biological Sciences
M.M. Moore, Department of Biological Sciences
M. O’Neill, Department of Chemistry
B.M. Pinto, Department of Chemistry
E. Plettner, Department of Chemistry
G. Prefontaine, Faculty of Health Sciences
P. Ruben, Department of Biomedical Physiology and Kinesiology
G.F. Tibbits, Department of Biomedical Physiology and Kinesiology
D.J. Vocadlo, Department of Chemistry
H. Yu, Department of Chemistry
*joint appointment with chemistry
**joint appointment with physics
***joint appointment with health sciences
Obtain information from the MBB graduate program assistant, Department of Molecular Biology and Biochemistry, 91ÅÝܽ, 8888 University Drive, Burnaby, BC, V5A 1S6, 778.782.5631, mbb@sfu.ca
See “1.3 Admission” on page 219 for requirements. Applicants should normally have completed some advanced course work in a related discipline.
Students are assigned a graduate supervisory committee which specifies appropriate work to meet or exceed the minimum requirements. Students are expected to attend the MBB research seminar series and participate regularly in a journal club.
Course Work
Minimum requirements are 12 graduate units including MBB 801 and up to three units of colloquia.
Research
A major part of the MSc is original research. A thesis describing the work is submitted and defended in accordance with Graduate General Regulations.
Course Work
For those with a BSc or equivalent, 18 units minimum is required, at least 15 of which must be graduate including MBB 801 and 806. This can include up to three MBB units. PhD students normally enrol in MBB 806 at the earliest opportunity following four program terms. With supervisory committee approval, MSc students may apply to the MBB graduate program committee for transfer to the PhD program.
For those entering with an MSc, six units minimum are required including MBB 806 and 801 if not already completed. MBB 806 must be completed at the first opportunity following two terms of program enrolment.
Research
A major portion of the program is original research. An original thesis is presented and defended according to “1.7.5 Doctoral Thesis” on page 223 of the Graduate General Regulations. In addition, all MBB candidates present a public seminar.
Graduate Diploma in Bioinformatics
The Department of Molecular Biology and Biochemistry and the School of Computing Science offers this program which provides advanced education in bioinformatics for students with a bachelor’s degree in molecular biology, cell biology, biochemistry, computer science, mathematics, or related disciplines. Admission is highly competitive.
This program supports students sponsored by the Canadian Institutes of Health Research (CIHR) Bioinformatics in Health Science Training Grant in which 91ÅÝܽ is a full partner with the University of BC and the BC Genome Sciences Centre. Students who are not part of the program are strongly encouraged to choose their courses from those offered at 91ÅÝܽ.
The program requires 33 units, with four core courses (12 units), three electives (9 units) and a minimum of two practicum rotation terms (12 units). Students must obtain a B or better in each course or practicum. The student’s advisory committee consists of a senior mentor and two other participating faculty members from the faculty at 91ÅÝܽ, UBC and the BC Genome Sciences Centre. In consultation with mentors, students will be assigned practicums based on needs, interest, and background. The result of the practicum is written in journal form for an oral presentation. The advisory committee will grade both the oral presentation and written report.
Core Courses
All four core courses should be completed in the first term, dependent upon term course offerings.
Students complete one of
CMPT 341-3 Introduction to Computational Biology
CMPT 771-3 Bioinformatics Algorithms
and one of
MBB 441-3 Bioinformatics
MBB 741-3 Bioinformatics
and one of
CMPT 505-3 Problem-based Learning in Bioinformatics*
MBB 505-3 Problem-based Learning in Bioinformatics*
and one of
CMPT 506-3 Critical Research Analysis**
MBB 506-3 Critical Research Analysis**
*course is completed at 91ÅÝܽ, BC Cancer Agency, and the Centre for Molecular Medicine and Therapeutics
**course is completed at 91ÅÝܽ and University of British Columbia
Elective Courses
In each of the first, second and third terms, students must also complete at least three elective courses in each term from the following.
CMPT 354-3 Database Systems I4
CMPT 740-3 Database Systems5
CMPT 761-3 Image Synthesis
CMPT 764-3 Visualization
CPSC 304-3 Database Management and Design4†
CPSC 504-3 Advanced Database Design and Data Mining5†
CPSC 536A-3 Topics in Algorithms and Complexity – Bioinformatics†
MEDG 505-3 Genome Analysis1†
MBB 331-3 Molecular Biology4
MBB 435-3 Genomic Analysis (or MBB 835)1
MBB 442-3 Proteomics (or MBB 842-3)
MBB 659-3 Special Topics in Bioinformatics2
MBB 669-3 Special Topics in Genomics2
MBB 679-3 Special Topics in Proteomics2
MBB 831-3 Molecular Evolution of Eukaryote Genomes
MBB 832-3 Molecular Phylogeny and Evolution
STAT 547-3 Statistical Problems Arising in Genomics†
STAT 890-4 Statistics: Selected Topics3
1 credit will be given for only one of MBB 435 or MEDG 505
2 special topics courses are given upon student demand and instructor availability
3 STAT 890 is a Special Topics course and course content will vary by course offering
4 CPSC 304, CMPT 354 and MBB 331 will not count toward elective requirements; they will be recommended if the student is deficient in either computational or life sciences background
5credit will be given for only one of CMPT 740 and CPSC 504
†course is completed at University of British Columbia
Practicum Courses
In addition to elective courses as outlined above, students complete the first practicum course in the second term, and the second practicum course in the third term, dependent upon course offerings. Students complete the practicums by choosing at least two of
CMPT 611-6 Research Rotation I (or MBB 611)*
CMPT 612-6 Research Rotation II (or MBB 612)*
CMPT 613-6 Research Rotation III (or MBB 613)*
*course is completed at 91ÅÝܽ, University of BC, and BC Cancer Agency
Courses Offered by Other Departments
Upon the supervisory committee’s recommendation and with the department graduate studies committee’s approval, MBB students may complete relevant courses from other departments toward their degree. Some courses of interest may include, but are not limited to CHEM 752, 754 and 811.
Graduate Course Work at Other Universities
With the supervisory committee’s recommendation and department graduate studies committee approval, up to six units completed elsewhere that didn’t result in a degree may apply to requirements, but not exceed more than half the required units in addition to MBB 801, 802 and 806.
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