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Department of Molecular Biology and Biochemistry

8166 South Science Building, 778.782.5630 Tel, 778.782.5583 Fax,

Chair

  • B.P. Brandhorst AB (Harv), PhD (Calif)

Professors Emeriti

  • R.J. Cushley BSc, MSc, PhD (Alta)
  • W.R. Richards AB, PhD (Calif)
  • M.J. Smith BSc (St Mary’s, Calif), PhD (Br Col)

Professors

  • D.L. Baillie BSc, MSc (Br Col), PhD (Conn), Canada Research Chair
  • B.P. Brandhorst AB (Harv), PhD (Calif)
  • R.B. Cornell BS (Houghton), PhD (Penn)*
  • W.S. Davidson BSc (Edin), PhD (Qu)
  • B.M. Honda BSc (McM), PhD (Br Col)
  • S. Jones BSc (Brist), MSc (S Fraser), PhD (Sanger)
  • L.M. Quarmby BSc, MSc (Br Col), PhD (Conn)
  • J.K. Scott AB (Occidental), MD (St Louis), PhD (Missouri), Canada Research Chair***
  • D. Sen BA (Camb), MPhil, PhD (Yale)*
  • J.L. Thewalt BSc, PhD (S Fraser)**

Associate Professors

  • C.T. Beh BSc, MSc (Calg), PhD (Prin)
  • F.S.L. Brinkman BSc (Wat), PhD (Ott)
  • M.A. Brockman BA (Beloit), PhD (Harvard)
  • N.J. Chen BSc (Fudan), MSS (Br Col), PhD (Chin Acad Sc)
  • S.M. Gorski BSc (S Fraser), MSc (Br Col), PhD (Wash, Mo)
  • N. Harden BSc (Br Col), PhD (Camb)
  • R. Holt BSc (Br Col), PhD (Alta)
  • M.R. Leroux BSc (McG), PhD (Br Col)
  • M.W. Paetzel BSc (Syr), BSc (Minn), PhD (Ohio State)
  • P.J. Unrau BSc (McM), PhD (MIT)
  • E.M. Verheyen BA (Cornell), MPhil, PhD (Yale)

Assistant Professors

  • J. Choy BSc (S Fraser), PhD (Br Col)
  • L. Craig BSc (Br Col), MSc, PhD (S Fraser)
  • N.C. Hawkins BSc, MSc (Calg), PhD (Prin)
  • F.F. Pio BSc, MSc (C Ferrand), PhD (Lille)
  • E.C. Young BSc (Tor), PhD (Brandeis)

Adjunct Professors

  • T.J. Borgford BSc, PhD (Manit)
  • R. Bruskiewich BSc (S Fraser), PhD (Br Col)
  • D. Granville BSc (S Fraser), PhD (Br Col)
  • M. Hirst BSc, PhD (Br Col)
  • K.Y. Leung BSA (Sask), PhD (Guelph)
  • M. Marra BSc, PhD (S Fraser)
  • J. Mills BSc (Qu), PhD (Br Col)
  • G.B. Morin BA (Carleton Coll), MSc (Calif), PhD (Colorado)
  • F. Ouellette BSc (McG), MSc (Calg)
  • E. Stringham BSc, MSc (Manit), PhD (Br Col)

Associate Members

  • T.V. Beischlag, Faculty of Health Sciences
  • A.J. Bennet, Department of Chemistry
  • N.R. Branda, Department of Chemistry
  • F. Breden, Department of Biological Sciences
  • T. Claydon, Department of Biomedical Physiology and Kinesiology
  • E. Emberly, Department of Physics
  • N. Forde, Department of Physics
  • N.H. Haunerland, Department of Biological Sciences
  • C. Krieger, Department of Biomedical Physiology and Kinesiology
  • P.C.H. Li, Department of Chemistry
  • C.A. Lowenberger, Department of Biological Sciences
  • M.M. Moore, Department of Biological Sciences
  • M. O’Neill, Department of Chemistry
  • B.M. Pinto, Department of Chemistry
  • G. Prefontaine, Faculty of Health Sciences
  • E. Plettner, Department of Chemistry
  • P. Ruben, Department of Biomedical Physiology and Kinesiology
  • G.F. Tibbits, Department of Biomedical Physiology and Kinesiology
  • D.J. Vocadlo, Department of Chemistry
  • H. Yu, Department of Chemistry

Senior Lecturers

  • I.C. Northwood BA (Vermont), PhD (Mass)
  • D.A.R. Sinclair BSc, MSc (Manit), PhD (Br Col)

Lecturers

  • S.F. Briscoe BSc (WLaur), PhD (McG)****
  • I.V. Kovalyova MA (Brown), PhD (Qu)

Advisor

  • Dr. I.C. Northwood BA (Vermont), PhD (Mass), 8142 South Science Building, 778.782.3536, inorthwo@sfu.ca

*joint appointment with chemistry

**joint appointment with physics

***joint appointment with health sciences

****joint appointment with biological sciences

Major, minor and honors are offered. Program entry requires MBB advisor permission. Seek advice from the advisor early and declare an intention to major at any time following the first term. Declared majors or honors students may follow the requirements in effect when they were accepted into the program, or the requirements as set out below.

Cumulative Grade Point Average Requirement

Acceptance into and continuance in the major requires a minimum 2.5 cumulative grade point average (CGPA) upon completion of lower division core courses (not including the CMPT courses).

Secondary school students admitted to the MBB major program via direct entry must achieve a 2.5 CGPA in all lower division required courses or be withdrawn from the program. Students declaring the MBB major must have completed all required lower division courses with a CGPA of 2.5 in those courses.

Prerequisite Grade

For a course to be accepted as fulfilling a prerequisite for any upper division MBB course, a student must have obtained a minimum grade of C.

Research and Directed Reading Courses

For degree credit, students are limited to nine undergraduate (or graduate) research and/or directed reading units. For an MBB honors, students are limited to a 18 undergraduate (or graduate) research courses and/or directed reading units. These include courses such as MBB 481, 482, 483, 490, 491, 492, 871, 872, 873 and corresponding courses offered by other departments (e.g. BISC 490, 491, 492, 498, 499, 888, 889, 890). If students complete more than nine (for the major) or 18 (for the honors) units of these courses, they may not apply the extra units toward the degree total (120 for major; 132 for honors). In addition, honors may not complete more than 15 research and/or reading units in one term.

Writing, Quantitative, and Breadth Requirements

Students completing degree programs must fulfil writing, quantitative and breadth requirements as part of their program. See “Writing, Quantitative, and Breadth Requirements” on page 7 for information.

Major Program

(120 units)

All students must complete lower and upper division requirements.

Lower Division Core Requirements

(52-53 units)

Students complete all of

BISC 101-4 Introduction to Biology

BISC 102-4 Introduction to Biology

BISC 202-3 Genetics

CHEM 121-4 General Chemistry and Laboratory I

CHEM 122-2 General Chemistry II

CHEM 126-2 General Chemistry Laboratory II

CHEM 215-4 Introduction to Analytical Chemistry

CHEM 281-4 Organic Chemistry I

CHEM 282-2 Organic Chemistry II

CHEM 286-2 Organic Chemistry Laboratory II

MBB 222-3 Molecular Biology and Biochemistry

MBB 231-3 Cell Biology and Biochemistry

and one of

CMPT 102-3 Introduction to Scientific Computer Programming

CMPT 110-3 Event-Driven Programming in Visual Basic

CMPT 120-3 Introduction to Computing Science and Programming I

and one of

MATH 150-4 Calculus I with Review

MATH 151-3 Calculus I

MATH 154-3 Calculus I for the Biological Sciences

and one of

MATH 152-3 Calculus II

MATH 155-3 Calculus II for the Biological Sciences

and one of

PHYS 101-3 General Physics I

PHYS 120-3 Modern Physics and Mechanics

PHYS 125-3 Mechanics and Special Relativity

PHYS 140-4 Studio Physics – Mechanics and Modern Physics

and one of

PHYS 102-3 General Physics II

PHYS 121-3 Optics, Electricity and Magnetism

PHYS 126-3 Electricity, Magnetism and Light

PHYS 141-4 Studio Physics – Optics, Electricity and Magnetism

Upper Division Core Requirements

(22 units)

Students complete all of

MBB 308-3 Molecular Biology Laboratory

MBB 309W-4 Biochemistry Laboratory

MBB 321-3 Intermediary Metabolism

MBB 322-3 Molecular Physiology

MBB 331-3 Molecular Biology

and one of

CHEM 360-3 Chemical Kinetics and Thermodynamics

MBB 323-3 Introduction to Physical Biochemistry

and one of

MATH 310-3 Introduction to Ordinary Differential Equations

STAT 201-3 Statistics for the Life Sciences

STAT 270-3 Introduction to Probability and Statistics

Students complete a minimum of five courses which include a minimum of one as indicated by # and a minimum of one as indicated by *. There is no upper limit on the quantity in this list that can completed.

MBB 402-3 Molecular Genetics

MBB 420-3 Special Topics in Biochemistry

MBB 421-3 Nucleic Acids#

MBB 422-3 Biomembranes#

MBB 423-3 Protein Structure and Function#

MBB 426-3 Immunology

MBB 432-3 Advanced Molecular Biology Techniques

MBB 435-3 Genomic Biology*

MBB 436-3 Gene Expression

MBB 437-3 Selected Topics in Signal Transduction

MBB 438-3 Human Molecular Genetics

MBB 440-3 Special Topics in Molecular Biology

MBB 441-3 Bioinformatics*

MBB 442-3 Proteomics*

MBB 443-3 Protein Biogenesis and Degradation#

PHYS 433-3 Biological Physics Laboratory

In addition to the above, students must complete enough electives to total 120. Of these120 units,

• 44 must be upper division

• 12 must be from outside the Faculty of Science, fulfilled as follows: six units from the Faculty of Arts and Social Sciences (excluding EDUC 401-406). Faculty of Applied Sciences courses may be used.

In addition, students should consult the bachelor of science regulations in Faculty of Science. See “Requirements for Major” on page 181.

Although many variations are possible, those with BC high school chemistry 12, mathematics 12 and physics 12 (or equivalents) might complete the following typical program.

Term 1

BISC 101-4 or 102-4

CHEM 121-4

MATH 150-4, 151-3 or 154-3

PHYS 120-3

Term 2

BISC 101-4 or 102-4

CHEM 122-2

CHEM 281-4

MATH 152-3 or 155-3

Term 3

CHEM 282-2

CHEM 286-2

MBB 222-3

PHYS 121-3

Term 4

BISC 202-3

CHEM 126-2

MBB 231-3

CMPT 102-3, 110-3 or 120-3

Levels 5 and 6

MBB 331-3

CHEM 360-3 or MBB 323-3

MATH 310-3 or STAT 201-3 or STAT 270-3

MBB 308-3, 309W-3, 321-3 and 322-3

MBB 432-3

nine units of electives Total 34 units

Levels 7 and 8

15-18 units; 11-16 units of electives Total 29-31 units

Honors Program

(132 units)

A minimum 3.0 CGPA, 3.0 upper division GPA, and department permission is required for admission. In addition to the major requirements, honors complete one of the following individual study term options.

either all of (option A)

MBB 481-5 Individual Study Semester – Research Design

MBB 482-5 Individual Study Semester – Research Performance

MBB 483-5 Individual Study Semester – Research Reporting

or both of (option B)

MBB 491-5 Undergraduate Research

MBB 492-10 Individual Study Semester*

*This may be accomplished by breaking the individual study term project into two consecutive terms.

Students complete 12 units outside the Faculty of Science (including six units in the Faculty of Arts and Social Sciences, but excluding EDUC 401 to 406) and at least 60 upper division units. See “Requirements for Major” on page 181.

Minor Program

(56-60 units minimum)

Lower Division Requirements

(42 units minimum)

Students complete all of

BISC 101-4 General Biology

BISC 102-4 General Biology

CHEM 121-4 General Chemistry and Laboratory I

CHEM 122-2 General Chemistry II

CHEM 126-2 General Chemistry Laboratory II

CHEM 281-4 Organic Chemistry I

CHEM 282-2 Organic Chemistry II

CHEM 286-2 Organic Chemistry Laboratory II

MBB 222-3 Molecular Biology and Biochemistry

MBB 231-3 Cell Biology and Biochemistry

and one of

MATH 150-4 Calculus I with Review

MATH 151-3 Calculus I

MATH 154-3 Calculus I for the Biological Sciences

and one of

MATH 152-3 Calculus II

MATH 155-3 Calculus II for the Biological Sciences

and one of

PHYS 101-3 General Physics I

PHYS 120-3 Modern Physics and Mechanics

and one of

PHYS 102-3 General Physics II

PHYS 121-3 Optics, Electricity and Magnetism

Cumulative Grade Point Average Requirement

Students must meet the same criteria as required for the MBB major program with the exception of BISC 202 which is not required for an MBB minor.

Upper Division Requirements

(14-18 units)

Students complete five upper division MBB courses (plus any lower division prerequisites) excluding MBB 481, 482, 483 and 492.

Computing Science and Molecular Biology and Biochemistry Joint Major Program

The School of Computing Science and the Department of Molecular Biology and Biochemistry co-operate in offering this joint major program. The student enrolment, appeals, and graduation processing are handled by either the School of Computing Science in the Faculty of Applied Sciences or the Department of Molecular Biology and Biochemistry in the Faculty of Science.

Lower Division Requirements

(63-67 units)

Students complete

CMPT 126-3 Introduction to Computing Science and Programming

or both of

CMPT 120-3 Introduction to Computing Science and Programming I

CMPT 125-3 Introduction to Computing Science and Programming II

and one of

MATH 150-4 Calculus I with Review

MATH 151-3 Calculus I

and all of the following

BISC 101-4 General Biology

BISC 102-4 General Biology

BISC 202-3 Genetics

CHEM 121-4 General Chemistry and Laboratory I

CHEM 122-2 General Chemistry and Laboratory II

CHEM 281-4 Organic Chemistry I

CHEM 282-2 Organic Chemistry II

CMPT 150-3 Introduction to Computer Design

CMPT 225-3 Data Structures and Programming

CMPT 275-4 Software Engineering

MACM 101-3 Discrete Mathematics I

MACM 201-3 Discrete Mathematics II

MATH 152-3 Calculus II

MBB 222-3 Molecular Biology and biochemistry

MBB 231-3 Cell Biology and Biochemistry

STAT 270-3 Introduction to Probability and Statistics

plus one of

PHYS 101-3 General Physics I

PHYS 120-3 Modern Physics and Mechanics

PHYS 125-3 Mechanics and Special Relativity

PHYS 140-4 Studio Physics – Mechanics and Modern Physics

plus one of

PHYS 102-3 General Physics II

PHYS 121-3 Optics, Electricity and Magnetism

PHYS 126-3 Electricity, Magnetism and Light

PHYS 141-4 Studio Physics – Optics, Electricity and Magnetism

Students are strongly encouraged to take CHEM 286.

Upper Division Requirements

(45 units)

Students complete all of

CMPT 307-3 Data Structures and Algorithms

CMPT 320-3 Social Implications of a Computerized Society

CMPT 354-3 Database Systems and Structures

CMPT 441-3 Introduction to Computational Biology

MBB 308-3 Molecular Biology Laboratory

MBB 331-3 Molecular Biology

MBB 441-3 Bioinformatics

STAT 302-3 Analysis of Experimental and Observational Data

plus one of

CMPT 376W-3 Technical Writing and Group Dynamics

MBB 309W-4 Biochemistry Laboratory

plus at least two of

CMPT 305-3 Computer Simulation and Modeling

CMPT 310-3 Artificial Intelligence Survey

CMPT 340-3 Computers in Biomedicine

CMPT 361-3 Introduction to Computer Graphics

MACM 316-3 Numerical Analysis

MBB 321-3 Intermediary Metabolism

plus at least three of

CMPT 405-3 Design and Analysis of Computing Algorithms

CMPT 413-3 Computational Linguistics

CMPT 419-3 Special Topics in Artificial Intelligence

CMPT 454-3 Database Systems II

MBB 423-3 Protein Structure and Function

MBB 435-3 Genomic Analysis

MBB 438-3 Human Molecular Genetics

MBB 442-3 Proteomics

Students must complete an additional two to three units to total 45 required upper division units.

Students should enrol in co-operative education.

Electives

Students must complete additional elective courses to bring the degree program total to 120 units.

Molecular Biology and Biochemistry and Business Administration Joint Major Program

This program offers in-depth combined training that is pertinent to development and administration in emergent biotechnology enterprises. Molecular biology and biochemistry form the scientific and technological underpinnings of today’s burgeoning biotechnology field while business administration teaches fundamentals of economics, management, marketing, investment and business law.

Students complete most required courses in both the department (MBB) and the Faculty of Business Administration (FBA). Upon completion, a bachelor of science from the Faculty of Science is awarded. The program requires 70 units in MBB-related courses and 52 in BUS-related ones with little curriculum scheduling flexibility. Students are strongly encouraged to participate in the co-operative education program.

Lower Division Molecular Biology and Biochemistry Requirements

Students complete all of

BISC 101-4 General Biology

BISC 102-4 General Biology

BISC 202-3 Genetics

CHEM 121-4 General Chemistry and Laboratory I

CHEM 122-2 General Chemistry II

CHEM 281-4 Organic Chemistry I

CHEM 282-2 Organic Chemistry II

MBB 222-3 Molecular Biology and Biochemistry

MBB 231-3 Cellular Biology and Biochemistry

and one of

MATH 150-4 Calculus I with Review

MATH 151-3 Calculus I

MATH 154-3 Calculus I for the Biological Sciences

and one of

MATH 152-3 Calculus II

MATH 155-3 Calculus II for the Biological Sciences

and one of

PHYS 101-3 General Physics I

PHYS 120-3 Modern Physics and Mechanics

PHYS 125-3 Mechanics and Special Relativity

PHYS 140-4 Studio Physics – Mechanics and Modern Physics

and one of

PHYS 102-3 General Physics II

PHYS 121-3 Optics, Electricity and Magnetism

PHYS 126-3 Electricity, Magnetism and Light

PHYS 141-4 Studio Physics – Optics, Electricity and Magnetism

CHEM 286 is strongly recommended.

Lower Division Business Administration Requirements

Students complete all of

BUS 251-3 Financial Accounting I

BUS 254-3 Managerial Accounting I

BUS 272-3 Behavior in Organizations

ECON 103-4 Principles of Microeconomics

ECON 105-4 Principles of Macroeconomics

and one of

BUEC 232-4 Data and Decisions I

STAT 270-3 Introduction to Probability and Statistics**

and one three-unit PHIL course.

Upper Division Molecular Biology and Biochemistry Requirements

Students complete all of

MBB 300-1 Special Topics in Biotechnology and Business

MBB 308-3 Molecular Biology Laboratory

MBB 309W-4 Biochemistry Laboratory

MBB 321-3 Intermediary Metabolism

MBB 322-3 Molecular Physiology

MBB 331-3 Molecular Biology

and any two 400 division MBB courses (except MBB 490 and 491), one of which can be fulfilled by completing BISC 303 or 333.

Upper Division Business Administration Requirements

Students complete all of

BUS 303-3 Business, Society and Ethics

BUS 312-4 Introduction to Finance

BUS 336-4 Data and Decisions II

BUS 343-3 Introduction to Marketing

BUS 360W-3 Business Communication

BUS 393-3 Commercial Law

BUS 477-4 New Venture Planning

and one of

BUS 347-3 Consumer Behavior

another marketing course

and one of

BUS 374-3 Organization Theory

BUS 381-3 Introduction to Human Resource Management

Computing Science and Molecular Biology and Biochemistry Joint Honors Program

To enter, students must meet the honors program admission requirements as specified by both departments, including seeking permission from the School of Computing Science. In addition to the major program requirements, students also complete six 400 division computing science units beyond those required for the joint major, and six research-related MBB units, which are fulfilled by completing MBB 496.

Molecular Biology and Biochemistry and Business Administration Joint Honors Program

(132-133 units)

Students must meet the criteria specified by each program (i.e. MBB and Faculty of Business Administration) for entering an honors program, and must seek MBB permission. In addition to the major requirements, MBB/business administration joint honors students must complete

• six units of 400 division BUS or BUEC courses beyond those required for the joint major

• a minimum of six units of research-related MBB courses, which can be fulfilled with MBB 496-6

Grade Point Averages

For program entry, continuance and graduation, the following grade point averages (GPAs) will be used: minimum 3.00 cumulative GPA; minimum 3.00 GPA for upper division courses.

Co-operative Education

Majors and honors students may apply to the science co-operative education program which includes up to five work terms during the normal academic program. See “Co-operative Education” on page 212.


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